Zoloft Withdrawal: All You Need to Know

Updated 03/21/24

Zoloft (Sertraline), a selective serotonin reuptake inhibitor (SSRI), is one of the most commonly prescribed antidepressants today. It’s approved to treat depression, anxiety, panic disorder, obsessive compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD). There are other off-label uses for Zoloft, like binge eating disorder and generalized anxiety disorder (GAD).

Despite its efficacy in treating multiple conditions, like any other medication or drug, there are potential risks and discontinuation symptoms to be aware of when stopping antidepressants like Zoloft suddenly. Research shows that up to 20% of people experience what’s known as antidepressant discontinuation syndrome, or antidepressant withdrawal syndrome when they abruptly stop taking their medication.

It doesn’t have to be this way, though. If the time ever comes, you can avoid many unpleasant SSRI withdrawal symptoms with the right plan, support, and guidance. From learning how long Zoloft withdrawal lasts, to discovering what to expect if you do go through it, here are a few things you should know so the process can be as safe and successful as possible. Keep reading for more information on withdrawal from Zoloft.

Can Zoloft Be Stopped Cold Turkey?

No — Zoloft (Sertraline) should not be stopped cold turkey. Zoloft is in a class of drugs known as selective serotonin reputable inhibitors (SSRIs). It’s not because of Zoloft addiction but rather the dependence that your body has built on the medication. Stopping an antidepressant medication too quickly can cause serious side effects. For example, many people report dizziness, nausea, and vomiting, among other symptoms, when they try to stop Zoloft without the right taper plan.

“If you’re thinking about discontinuing taking Zoloft, it’s important to keep in mind that stopping any medication cold turkey can be dangerous. It’s always advised that you talk to your doctor or psychiatrist first.”

– Talkspace Therapist, Dr. Olga Molina, D.S.W., LCSW

Sertraline withdrawal is something to be expected and it is important that you stop taking this medication the right way, to avoid or reduce these side effects.

If you want to come off your antidepressant — and this is true for any of them, not just Zoloft — you must speak with your doctor first.

Withdrawal Symptoms of Zoloft

When you start your Zoloft detox, you might experience some common withdrawal symptoms. It’s important to note that some people won’t go through any withdrawal from an SSRI antidepressant.

If you do experience symptoms, though, they can usually be managed and controlled. Symptoms can vary from person to person, depending on body chemistry, dosage, and other factors.

Emotional symptoms

Emotional symptoms that are commonly associated with Zoloft withdrawal might include:

• Anxiety
• Irritability
• Depression
• Mood swings
• Difficulty concentrating or focusing on tasks
• Insomnia or excessive sleeping
• Fatigue or lethargy
• Suicidal thoughts
• Intensified feelings of guilt or worthlessness

Some people may experience increased cravings for drugs or alcohol. When experiencing these thoughts or feelings, it is important to always practice self-care and take care of yourself, so you can feel your best. You can also try one of the many types of therapy, which can help you sort out and manage the strong emotional symptoms you may be facing.

Physical symptoms

Physical symptoms associated with withdrawal from Zoloft may include:

• Nausea and vomiting
• Dizziness or vertigo
• Headaches
• Muscle aches/pains
• Sweating more than usual
• Feeling weak
• Trembling hands
• Dry mouth
• Changes in appetite (increased hunger)
• Weight gain/loss
• Blurred vision
• Ringing in the ears (tinnitus)
• Heart palpitations

Many people report flu-like symptoms such as fever, chills, body aches, and joint pain.

Why Does Zoloft Withdrawal Happen?

Zoloft withdrawal occurs because the body has become accustomed to the presence of the drug. As a selective serotonin reuptake inhibitor (SSRI), Zoloft increases the amount of serotonin in the brain, which helps improve mood and reduce anxiety. Over time, the body adjusts to this increased serotonin level, leading to physical dependence on Zoloft. 

When Zoloft is suddenly discontinued, the body experiences a shock due to the sudden absence of the drug, leading to withdrawal syndrome. This SSRI withdrawal syndrome is a direct result of the body’s attempt to rebalance its serotonin levels without the influence of Zoloft, which can lead to a range of discontinuation symptoms.

Discontinuation vs. Relapse of Mental Health Symptoms

It’s important to differentiate between Zoloft detox symptoms and a relapse of the underlying mental health condition. Discontinuation symptoms often mimic the symptoms of the conditions Zoloft was prescribed to treat, such as depression and anxiety. However, these withdrawal symptoms are temporary and directly related to the body adjusting to the absence of Zoloft.

A relapse means the return of depression, anxiety, or other symptoms for which Zoloft was originally prescribed. Relapse indicates the need for ongoing treatment or treatment programs, not just the body’s reaction to stopping medication.

Understanding this distinction is crucial for proper management. While discontinuation symptoms suggest that the body is adapting to the lack of medication, a relapse may require a reassessment of treatment options, possibly including resuming Zoloft under medical supervision or exploring Zoloft alternatives.

How Long Does Zoloft Withdrawal Last?

Zoloft withdrawal can last anywhere from a few days to several weeks after you take your last dose. The severity of symptoms will vary and ultimately depend on the factors like body chemistry and dosage taken before discontinuation.

While some people may not experience any withdrawal effects, others can find them unbearable or even dangerous if left untreated.

The trick to stopping Zoloft (or any other antidepressant) without experiencing severe withdrawal symptoms is to wean off your medication slowly.

Zoloft withdrawal timeline

When trying to determine how long Zoloft withdrawal lasts, understanding the timeline can help. A Zoloft withdrawal timeline depends on things like you, your body chemistry, your dose, and how long you took the medication.

Slowly tapering off Zoloft over several weeks is an excellent example of a Zoloft withdrawal timeline plan.

When does Zoloft withdrawal peak?

“Zoloft withdrawal symptoms peak at 36 to 96 hours after stopping Zoloft and could last up to 6 weeks.”

– Talkspace Therapist, Dr. Olga Molina, D.S.W., LCSW

How to Cope with a Zoloft Withdrawal

If you plan on stopping Zoloft and are worried about experiencing withdrawal, here are some tips to avoid most or all the symptoms.

• Recognize the symptoms: Common withdrawal symptoms of Zoloft include dizziness, nausea, headache, insomnia or vivid dreams, anxiety, and irritability. When you’re aware of and recognize these signs, you can address them as soon as possible.
• Talk to your doctor: If you experience any of these symptoms after stopping your medication, talk with your doctor about what might help. For example, tapering off more slowly or switching medications might be necessary.
• Get support from friends and family: During this time, support from friends and family can make a massive difference in helping you cope more effectively with the withdrawal process. They can provide emotional support and understanding when things get tough for you emotionally or physically due to the withdrawal process.
• Exercise regularly: Exercise can be effective in reducing stress levels and improving overall mental health. Even light exercise — something as simple as walking around your neighborhood for 30 minutes — can improve your mood.
• Take time for yourself: Taking time out of each day just for yourself, whether you read a book, listen to music, or meditate, can help reduce stress levels while dealing with withdrawal from Zoloft. Sometimes, a little self care can give you a much-needed break, helping to clear your mind and allowing you to think more clearly without feeling overwhelmed by emotions caused by Zoloft withdrawal symptoms.
• Natural remedies: In addition to professional medical advice, incorporating natural remedies for depression might offer complementary support to ease the transition and manage withdrawal symptoms more holistically.

“To safely come off Zoloft and avoid withdrawal symptoms, speak to your doctor who will slowly lower the dosage over time so your body does not experience abrupt discontinuation of the drug.”

– Talkspace Therapist, Dr. Olga Molina, D.S.W., LCSW

How to Come off Zoloft Safely

Transitioning away from Zoloft necessitates a strategic, well-considered approach that goes beyond managing withdrawal symptoms. It involves a holistic plan encompassing your physical, emotional, and lifestyle considerations to ensure a smooth and safe process. 

Here are strategies used to navigate this period:

Consult with your healthcare professional

Work closely with your healthcare provider to create a customized tapering schedule. This plan should consider your medical history, the duration and dosage of your Zoloft treatment, and any other factors unique to your health profile.

Schedule regular appointments with your healthcare provider throughout the tapering process. These check-ins can help adjust your tapering plan as needed based on your feedback and any symptoms you might experience.

Explore holistic health management

Engage with a nutritionist or do your research on how certain foods can support brain health and mood regulation. A balanced diet rich in omega-3 fatty acids, antioxidants, and vitamins can play a supportive role in managing mood fluctuations during the tapering period.

Consider incorporating mindfulness practices, such as meditation or yoga, into your daily routine. These practices can help manage anxiety and stress levels, providing a sense of calm and balance during the transition.

Maintain good sleep hygiene

Prioritize good sleep practices, as rest plays a critical role in emotional and physical health. Establish a regular sleep schedule, create a relaxing bedtime routine, and optimize your sleeping environment for comfort and tranquility.

Seek support

Lean on your support network of friends, family, or support groups. Sharing your experiences and hearing others’ stories can provide comfort and insights during your transition.

Talk with a Licensed Psychiatrist

You should always speak with a qualified mental health professional before discontinuing antidepressant medications like Zoloft. Your doctor can help assess and guide you on the safest way to stop taking this medication and minimize Zoloft withdrawal symptoms. They also might recommend alternative treatments or lifestyle changes that could reduce your need for Zoloft altogether. 

Coming off Zoloft can be a difficult process, but with the right guidance and support from a licensed psychiatrist, it is possible to do so safely and easily.

Virtual consultations with Talkspace’s psychiatrists are available to properly assess your needs. With their knowledge, licensed professionals may prescribe Zoloft online to relieve your symptoms or help advise if you are thinking about getting off the medication.