Can Adderall Cause Depression?

The Relationship Between Adderall and Depression

Depression is a common condition that impacts the lives of an estimated 280 million people around the world, according to the World Health Organization (WHO). Despite its prevalence, depression is highly treatable. Sometimes, people use the drug Adderall for depression symptom relief. That said, just like any drug, not everyone will have the same experience with Adderall and depression. 

The relationship between Adderall and depression isn’t fully understood. Some people using Adderall for depression find relief, while for others using it for ADHD, the drug might actually cause depression symptoms.

Adderall causing depression

Wondering if Adderall can cause depression? According to the FDA, depression is a potential side effect of Adderall. However, it’s worth noting that Adderall depression is very rare, and it typically only happens as the result of Adderall abuse or misuse. 

If you’re prescribed Adderall, it’s important to know that you should never abruptly stop taking it without guidance from your doctor. That’s because when taken in high doses for a long time, Adderall withdrawal symptoms can include symptoms of depression if you suddenly stop taking it. 

Adderall as an off-label treatment for depression

Adderall is listed as a psychostimulant, which means it can improve mood, concentration, and energy — all things that depression can severely impact. Because of this, Adderall might be prescribed to treat your depression. While it’s not technically an antidepressant, Adderall is used as a depression medication in cases where other drugs haven’t been effective in relieving your symptoms.

In studies, psychostimulants like Adderall were found to be particularly effective in treatment-resistant depression.

Mechanisms That May Link Adderall & Depression

Several mechanisms can help explain more about how and why Adderall depression might exist.

For example:

• Some experts are concerned that Adderall causes prolonged stimulation of the central nervous system, which could lead to neurotransmitter dysregulation. 
• An abrupt withdrawal of Adderall after long-term use might trigger symptoms of depression as the brain tries to adjust to not having the neurotransmitter boost Adderall offers. 
• Adderall can have an impact on sleep and appetite in some people, which might contribute to mood disturbances over time. 

Although more research is needed for us to understand fully, there are other common theories about Adderall causing depression that should be noted and carefully considered.

Rebound effects

Rebound refers to the temporary worsening of symptoms or the emergence of new symptoms as a medication wears off. When the effects of Adderall subside, some people might feel a rebound effect that results from a temporary decrease in neurotransmitter activity. 

Rebound effects can lead to changes in mood, focus, and productivity — these fluctuations might increase what can be referred to as Adderall depression.  

Psychological dependence

Dependence is always a concern when taking any psychiatrist-prescribed medication. Psychological dependence on Adderall, while not likely when used appropriately, can develop in some people, particularly in cases where the drug is misused. 

In some cases of dependence, it’s possible to experience worsened symptoms of anxiety or depression, especially if someone can’t access or use their medication unexpectedly. Being reliant on any drug like Adderall to ensure cognitive performance can cause feelings of being out of control and increase depressive symptoms. Adderall addiction treatment options should be explored in such situations.

Pre-existing vulnerabilities

Pre-existing vulnerabilities — like a history of depression, anxiety, or another mental health condition — might increase the likelihood of experiencing depressive symptoms after taking Adderall. 

People with underlying mood disorders, like bipolar disorder, might be more susceptible to the impact a medication has on neurotransmitter levels. This can lead to heightened depressive symptoms, especially if there are also genetic predispositions or environmental stressors present that might interact with Adderall.

Talk to a Mental Health Professional

If you’re struggling with depression and are considering medication, or if your ADHD medication isn’t working as well as you had hoped, talk to a mental health professional. Talkspace is convenient and makes the process of getting mental health care easy, so you don’t have to add more stress to your plate.

Get the help you need from online psychiatrists at Talkspace, who are licensed, experienced, and available to help you explore Adderall alternatives so you can get back to living a happy, healthy life with less depression or ADHD affecting you.

Connect with an online therapist or psychiatrist today so you can start building your own ADHD or depression coping skills to complement your treatment.