Updated On: May 16, 2024
Zoloft (sertraline) is a commonly prescribed antidepressant medication that’s FDA-approved to treat depression and certain types of anxiety disorders — like generalized anxiety disorder (GAD) social anxiety disorder, post-traumatic stress disorder (PTSD), and obsessive-compulsive disorder (OCD).
Getting help for anxiety is brave. It can be a game-changing decision for your mental health condition that allows you to return to your life. For many, Zoloft is an excellent addition to a comprehensive anxiety treatment plan.
Learn more about Zoloft and anxiety here — including how it works, its benefits, and what to consider before taking it.
Is Zoloft good for anxiety? In short, yes, but it depends on the type of anxiety you’re experiencing. Zoloft belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs). These antidepressant medications work by altering serotonin levels in the brain. Increasing serotonin helps regulate mood and emotions, things that anxiety impacts.
Zoloft also affects dopamine levels, which is linked to improved motivation and satisfaction. In studies, Zoloft was found to reduce the frequency and severity of panic attack episodes. Other research also suggests using Zoloft for anxiety in social settings can effectively reduce symptoms and boost self-confidence.
Get an evaluation and prescription for Zoloft from a psychiatric provider licensed in your state.
Zoloft isn’t the right prescription for every type of anxiety disorder. Like all mental health conditions, the same drug won’t work the same way for everyone. So, even though Zoloft for anxiety disorders might work for one person, it may not be as effective, or effective at all, for another, and efficacy widely depends on the type of condition being treated.
Anxiety disorders Zoloft can be used to treat can include:
How long Zoloft takes to work will vary from person to person and can depend on numerous factors. Research from the National Alliance on Mental Illness notes that some people start experiencing improvement in symptoms — such as sleep, appetite, or energy — in 1 – 2 weeks after starting Zoloft. Many won’t see symptom improvement — like increased interest in activities — for several weeks up to a couple of months.
Like most selective serotonin reuptake inhibitor antidepressants, Zoloft takes time to build up in your system, which might make significant symptom improvement less evident in the beginning. While you may see reduced or improved symptoms in a couple of weeks, full therapeutic effects may not be felt for up to 6 weeks or longer.
Factors that can impact how quickly Zoloft works for anxiety include:
Like all drugs, Zoloft has potential side effects you should be aware of. Knowing what to look for when taking a new drug is beneficial on two fronts. First, it can let you know a drug is working. Some minor side effects can resolve on their own over time, so you can just think of them as a sign that Zoloft is doing its job. Also, understanding the full scope of possible side effects of Zoloft means you’ll be better educated on when and if you should mention something to your doctor.
While rare, these side effects can indicate Zoloft is not working for you as intended. Reach out to your doctor or seek immediate care if you experience any of the above reactions after taking Zoloft.
Zoloft comes in multiple forms and should be taken daily with or without food. Your doctor will give explicit dosage instructions, but in general, when using Zoloft to treat symptoms of anxiety, the starting dosage is 25 mg per day with possible gradual increases per your doctor’s direction.
Zoloft dosages can be increased by 25 to 50 mg per week based on your response and how well you tolerate the drug. The therapeutic dose for anxiety ranges from 50 to 200 mg per day.
Expert Insight
“Zoloft dose may vary depending on the severity of the anxiety symptoms, as well as if used alone in conjunction with any other medication. Usually, the therapeutic doses for severe anxiety disorders need much higher doses of Zoloft, as compared to for depression.”Psychiatrist, MD, DFAPA Muhammad Munir
Optimal Zoloft dosage varies on factors like severity of symptoms, height and weight, history of other mental health conditions, other medication you currently take, family history, and more.
Never stop taking Zoloft without talking to your doctor or a medical professional and getting a proper taper dose schedule. Zoloft withdrawal symptoms can be serious, causing what’s known as antidepressant discontinuation syndrome in up to 20% of people who cease taking their medication.
When starting Zoloft for anxiety disorder treatment, it’s essential to consult with your healthcare provider to discuss potential risks and other considerations.
Factors you should take into consideration before deciding to take this drug include:
Expert Insight
“Zoloft is a great choice for anxiety disorders. The dose is adjusted gradually, so the tolerance is not an issue. Never miss high doses of Zoloft, as that can cause severe withdrawals.”Psychiatrist, MD, DFAPA Muhammad Munir
Anxiety can be a debilitating condition that impacts your life, relationships, and ability to function daily. Fortunately, it’s highly treatable. Medication like Zoloft for anxiety, especially when combined with other treatment options like therapy for anxiety, can be an effective way to address symptoms.
Talkspace makes access to mental healthcare simple and affordable. Whether you’re looking for therapy, anxiety medication, or both, Talkspace can be the solution you’re looking for. Talkspace online psychiatrists are licensed and experienced in diagnosing and treating anxiety symptoms through personalized anxiety treatment plans that might include therapy and the use of prescription medications like Zoloft.
Get connected with a Talkspace psychiatrist to get a prescription for Zoloft online.
World Health Organization. September 27, 2023. Accessed March 25, 2024.
Hobgood, C.D., Clayton, A.H. 2009;45(5):351. doi:10.1358/dot.2009.45.5.1362066. Accessed March 25, 2024.
Liebowitz MR, DeMartinis NA, Weihs K, et al. The Journal of Clinical Psychiatry. 2003;64(7):785-792. doi:10.4088/jcp.v64n0708. Accessed March 25, 2024.
NAMI: National Alliance on Mental Illness. National Alliance on Mental Illness. January 2024. Accessed March 25, 2024.
Gabriel M, Sharma V. Canadian Medical Association Journal. 2017;189(21). doi:10.1503/cmaj.160991. Accessed March 25, 2024.
Dr. Muhammad Munir, MD, DFAPA, has over 20 years of clinical experience specializing in mood disorders, anxiety disorders, bipolar disorder, PTSD, panic disorder, and ADHD. Dr. Munir believes in “back to basics” the therapeutic alliance between the physician and patients. The hallmark of this alliance is the emphatic process whereby the patient is not only enabled, but educated and encouraged, to take an active role in their psychiatric care and wellbeing.