Prescription Medication Alternatives to Xanax

Xanax is in the class of drugs known as benzodiazepines, a type of anti-anxiety medication. This prescription medication works by binding to the GABA-A receptor to raise neurotransmitter levels in the brain, creating a calm, relaxed state. Several alternative medications for Xanax work well to alleviate anxiety, both in the same and different classes of drugs. 

Other benzodiazepines that treat anxiety

• Klonopin (clonazepam): Reduces excitement in the brain and has a longer half-life
• Ativan (lorazepam): Has a rapid onset of action for fast relief
• Valium (diazepam): Has muscle-relaxing properties that offer a calming effect

Selective serotonin reuptake inhibitors (antidepressants) that treat anxiety

• Zoloft (sertraline): Increases levels of the neurotransmitter serotonin in the brain to improve mood and relieve anxious feelings
• Prozac (fluoxetine): Balances serotonin levels, alleviating symptoms of anxiety
• Lexapro (escitalopram): Enhances serotonin activity, regulating mood and decreasing anxiety

Serotonin and norepinephrine reuptake inhibitors (antidepressants) that treat anxiety

• Effexor (venlafaxine): Raises serotonin and norepinephrine levels to improve mood and reduce symptoms of anxiety
• Cymbalta (duloxetine): Boosts serotonin and norepinephrine in the brain

Beta-blockers that treat anxiety:

• Propranolol: Blocks the effects of adrenaline, like rapid heart rate or tremors; often used for situational anxiety like public speaking

Natural Alternatives to Xanax

People with generalized anxiety disorder seeking natural alternatives to Xanax have multiple options. Relief can come from natural alternative medication, herbal remedies, or therapeutic practices without needing a prescription anti-anxiety medication or having to worry about the risk of dependency or drug abuse. Many of the following remedies and holistic coping techniques may help with anxiety. 

“Taking care of anxiety with natural remedies is the best option as it reduces the chances of addiction, as is the case with benzodiazepines. The regular long-term use of Xanax can also cause depression further complicating the treatment.”

– Talkspace psychiatrist, Dr. Muhammad Munir

Chamomile

Chamomile, a commonly used natural remedy for anxiety, is known for its calming properties. It can be consumed as a tea or a supplement, and studies suggest it can effectively reduce symptoms of anxiety and improve overall psychological well-being. 

Lavender

Loved for its soothing, pleasant scent, lavender is commonly used in essential oils for anxiety, sachets, diffusers, and candles. Research shows that inhaling lavender for just 3 minutes can decrease anxiety and enhance mood. 

Valerian root

Some people use valerian root for anxiety because it may promote sleep and relaxation and can significantly reduce anxiety in some people. Its sedative effects make it a popular choice for people looking for a natural way to manage both anxiety and insomnia. However, like prescription medications, valerian can have side effects and can negatively interfere with other natural supplements or prescription meds. Make sure to talk to your doctor before trying it.

Passionflower

Passionflower can have positive effects on symptoms of anxiety, and several studies suggest it may be a promising alternative to prescription drugs. One study found that people who took an herbal extract containing passionflower saw significantly reduced symptoms of generalized anxiety disorder (GAD). 

Therapy

Several forms of therapy are used to successfully manage anxiety — often without the use of medication. Cognitive behavioral therapy (CBT) and mindfulness-based therapy are 2 types of therapy for anxiety known for their efficacy in reducing symptoms. 

Self-help techniques

There are several self-help techniques that can be incorporated into daily routines to drastically reduce symptoms and help manage anxiety over time. Many work as an effective stand-alone treatment, and others have enhanced effectiveness when combined with additional forms of treatment like medication or natural alternatives. 

Some helpful coping skills for anxiety include:

• Mindful meditation teaches you to focus on the present so you can gain a calm, clear perspective on your thoughts instead of worrying about the past or future.
• Exercise: Regular activity improves physical health and releases endorphins to naturally boost mood.
• Get enough sleep: Quality sleep is crucial for managing anxiety. Develop a bedtime routine that promotes relaxation and consistent sleep and wake times—even on the weekend. Limiting screen time before bed is also a good way to improve sleep health.
• Journal: Journaling for anxiety can help you find patterns or triggers that are contributing to your anxiety. Then you can either avoid them or find coping skills to manage them. 
• Eat healthy: Minor dietary adjustments—for example, limiting anxiety-inducing foods like caffeine and sugar—can have a positive effect on symptoms. Eating more brain-boosting foods that contain omega-3 fatty acids can also reduce stress.
• Find social support: Build and maintain a strong network of friends and family who can offer emotional support when you need it. Support systems also help reduce feelings of isolation that are common with anxiety.
• Relaxation techniques: Yoga, Tai Chi, and guided imagery are all positive ways to reduce anxiety.

“Research has proven medications and therapy are the best way to treat anxiety. Therapy builds skills and strategies to address anxiety long-term. Meds are the bridge to get through the situations and learning cognitive ways to handle the daily challenges is the goal.”

– Talkspace psychiatrist, Dr. Muhammad Munir

Over-the-Counter (OTC) Alternatives to Xanax

There are several over-the-counter (OTC) options that can help alleviate anxiety symptoms. Supplements and herbal remedies can be appealing to those seeking fast relief without the need for a prescription. OTCs are easily accessible and readily available in most areas or by ordering online. 

Nootropic supplements

Nootropic supplements — commonly referred to as “smart drugs” — can improve cognitive function and reduce anxiety. Some studies say they work by enhancing brain health and neurotransmitter function.

Magnesium supplements

For those looking for nonprescription alternatives, you can look into using magnesium for anxiety. It’s crucial for neurotransmitter regulation and it impacts the nervous system for improved mental health. Studies suggest that magnesium supplements can be beneficial in managing mild anxiety.   

Herbal supplements

Herbal supplements like ashwagandha, Rhodiola, and kava are increasingly popular holistic options for treating anxiety. These natural remedies work by interacting with the body’s stress-response system or impacting neurotransmitters to offer a calming effect and reduce anxiety symptoms.

Vitamin B complex

B vitamins are essential for maintaining good mental health. Research has shown that high doses of vitamin B can reduce anxiety, stress, and depression. 

Find Effective Treatments with Talkspace

If you’re seeking Xanax alternatives to help manage your symptoms of anxiety, Talkspace can help. 

Get comprehensive, convenient guidance and solutions through an online platform that connects you with qualified, licensed therapists and psychiatrists who can introduce you to a variety of effective options. From other anxiety medications and holistic treatments to therapeutic approaches, Talkspace makes accessing complete mental health support easy. 

Getting therapy and a practical, personalized treatment plan that fits your needs from the comfort of your home is possible. Talkspace offers an accessible, affordable way to enhance your mental well-being and take control of your anxiety. 

Get online psychiatry and medication prescriptions and management from Talkspace by reaching out today.

How Fast Does Wellbutrin Work?

The onset of action of any drug can vary from person to person. Wellbutrin is proven in studies to be typically well-tolerated and can be an alternative solution for people who don’t find successful relief from more traditional antidepressants, like SSRIs and SNRIs. 

For some people who take Wellbutrin, noticeable improvement in depressive symptoms may be experienced within a couple of weeks. Most often, the first changes seen are in improved sleep, energy, and appetite. Keep in mind, though, that you might not experience the full benefits of an antidepressant for 4 – 6 weeks or longer, so patience is important. 

It’s also worth noting that studies found improvement in sleep is often seen before any significant mood changes when taking Wellbutrin. 

Factors That Affect How Long It Takes Wellbutrin to Work

Research supports Wellbutrin’s efficacy in treating depression and other conditions in adults, but it doesn’t work the same way or on the same timeline for everyone who takes it. Several factors can impact how long it takes to be effective. Wellbutrin dosage, symptom severity, genetic factors, comorbid conditions, other medications, and more can all influence how long it takes a drug to fully work. 

Dosage adjustments

Adjusting the dose of a medication will naturally affect how long it takes to work. Your doctor may want to increase the dose if it’s been long enough to know that your current dose isn’t working as it should. Higher doses might lead to a faster onset of action. Decreasing or missing a dose might delay how long it takes Wellbutrin to work. 

It’s important to note that an individual’s weight will also impact the rate at which the body absorbs the antidepressant medication. If you are undergoing a weight management regime, notify your healthcare provider so they can prescribe the proper Wellbutrin dosage.

It’s vital to take Wellbutrin precisely as directed. Never change your dose without your doctor’s or healthcare provider’s guidance.   

Individual factors

Individual factors like body chemistry can significantly impact how long a drug takes to work. Everything from metabolism rate to genetics to overall health can come into play. 

Individual factors include:

• How fast (or slow) your metabolism is
• Genetic factors like your height, weight, or family history
• Previous history of depression or other mental health conditions
• Other medications you’re taking or have taken in the past

Interaction with other medications

Every drug can potentially interact with other medications. Some interactions between Wellbutrin and other drugs can have dangerous possible outcomes — this is why it’s so critical that your doctor is aware of everything you’re taking. 

From other prescription medications to over-the-counter (OTC) herbal supplements and vitamins for depression, make sure your doctor has a comprehensive list of anything you regularly take. 

Certain drugs known to interact with Wellbutrin include:

• Selective serotonin reuptake inhibitors (SSRIs) 
• Serotonin-norepinephrine reuptake inhibitors (SNRIs)
• Monoamine oxidase inhibitors (MAOIs)
• Tricyclic antidepressants (TCAs)
• Antipsychotic medications
• Anticonvulsant medications
• Nicotine replacement therapy (NRT)
• Alcohol

How to Know if Wellbutrin is Working

Because it doesn’t work immediately, monitoring your symptoms over time will be critical. Some initial signs Wellbutrin is working for you include improved mood or energy level, focus, and overall well-being. 

“You can tell your medication is working by examining progress in your main symptoms. Has your energy, sleep, and/or concentration improved? Are you more hopeful? Are you more motivated to get back to your hobbies?”

– Talkspace psychiatrist Dr. Dion Metzger, MD

Improved mood

Consistently taking Wellbutrin can enhance mood over time. You might experience reduced hopelessness or sadness and find a returned interest in daily activities. Overall, Wellbutrin can lead to greater well-being in some people. Some research found Wellbutrin significantly reduced depression scores in 24 out of 27 trials. 

Increased energy levels

Like most antidepressants, studies show that Wellbutrin can increase energy levels. It helps some people feel more alert and awake. It can also improve motivation levels throughout the day. A boost in energy can lead to improved productivity and a renewed interest and engagement in social and other activities.

Restored interest in activities

Depression is intrinsically linked with a lack of interest in things once enjoyed. According to studies, Wellbutrin might help you find renewed joy in hobbies, social gatherings and interactions, and basic daily routines and functioning. Specifically, the drug has been found to decrease negative emotional processing and increase reward processing. 

Improved sleep patterns

Often one of the first improvements felt, healthy sleep habits are commonly reported by people taking Wellbutrin. In research, Wellbutrin was found to be a potential treatment for those with depression combined with fatigue and sleepiness. It doesn’t appear to suppress REM sleep, and sleep disruption isn’t common.  

Increased social interactions

When you feel better, your willingness and desire to be more socially engaged are natural side effects. Sociability can strengthen relationships and enhance the feeling of connectedness, which are important for people with depression. Some research even suggests that Wellbutrin might be an effective treatment for social phobia. 

Overall improvement in quality of life

Wellbutrin may improve the overall quality of life for many people who take it. Improved mood, energy levels, interest in others and activities, and more can all result in an enhanced sense of satisfaction and fulfillment in life. 

Increased sex drive

While many antidepressants are linked to sexual dysfunction, some studies suggest Wellbutrin may actually improve sex drive. More research is still needed, but for now, the drug is associated with a lower risk of sexual side effects and the potential to improve sex drive when compared to most other depression drugs. 

What to Do When Wellbutrin is Not Working

The most important thing to do if you’re worried Wellbutrin isn’t working for you is to be patient. It can be difficult, but try to give it at least a month before trying something different. Stay in contact with your doctor or mental health provider, and be sure to share what you’re experiencing along the way — especially if your symptoms worsen or you’re experiencing side effects of Wellbutrin.

“If Wellbutrin is not working as it should, give it time. It often starts working between 2 – 4 weeks. If you’re not seeing benefit or just seeing some benefit at the 4-week mark, your provider may suggest a dose increase.”

– Talkspace psychiatrist Dr. Dion Metzger, MD

If Wellbutrin isn’t working for you after 4 – 6 weeks, your doctor might:

• Change your dosage
• Change your depression medication
• Add another medication to your treatment plan
• Suggest you combine your medication with therapy (if you’re not already seeking it)
• Encourage other lifestyle changes (like eating a healthy diet, getting enough sleep, and working out) 

Get Personalized Mental Health Treatment with Talkspace

Talkspace offers expert, skilled mental health advice and support from qualified, licensed mental health professionals. If you have questions like how long it takes for Wellbutrin to work, or if you’re seeking therapy, a diagnosis, or medication management, Talkspace makes getting help simple, affordable, and convenient. 

Start your journey toward improving your life — online prescriptions make it easy. Reach out today to connect with an online psychiatrist and learn about Wellbutrin.

Common Side Effects You Might Expect With Wellbutrin

All prescription drugs have possible side effects that can range from mild to severe. Most will occur within a few days to a few weeks of starting certain medications. For some people, side effects will lessen as the body adjusts to a medication. 

Wellbutrin side effects in the first week can include:

• Headache
• Difficulty sleeping
• Nausea
• Constipation
• Sore throat

Other common side effects of Wellbutrin you might experience include:

• Dry mouth
• Increased sweating
• Decreased appetite (which can lead to weight loss on Wellbutrin)
• Dizziness
• Stomach pain
• Restlessness
• Agitation

Less Common Side Effects of Wellbutrin

There are also some less common, but still possible, side effects of Wellbutrin. These might include: 

• Change in sense of taste
• Blurred vision
• Rapid heartbeat 
• Drowsiness
• Rash 
• Muscle pain
• Ringing in the ears
• Sore throat
• Frequently needing to urinate

Serious Side Effects of Wellbutrin

Your doctor will inform you of the serious side effects from Wellbutrin to be aware of. Knowing what to look for before you start taking a drug is vital so you can immediately seek professional help if necessary. 

Risk of seizures

Although rare, studies show a known risk of seizure is linked to higher doses of Wellbutrin. It’s important to point out that this risk is dose-dependent, which means the risk increases with a higher dose or when the drug isn’t used as indicated. 

Factors that may increase the risk of Wellbutrin-related seizures include:

• Having a history of seizures
• Taking high doses of Wellbutrin
• Abruptly stopping Wellbutrin
• Other medical conditions, including but not limited to disordered eating or brain injuries
• Drug interactions

Allergic reactions

Some people can have an allergic reaction to Wellbutrin. If you have any of the following signs after you take this drug, seek care as soon as possible. Discuss any known allergies you’re aware of with a medical professional before taking Wellbutrin. 

Signs of allergic reactions may include:

• Developing a rash or hives
• Swelling of the face, lips, throat, or tongue
• Having difficulty breathing
• Going into anaphylactic shock

Certain psychological side effects

It’s possible to have psychological side effects while taking Wellbutrin. Note that not everyone will experience these adverse effects, and it’s common that the benefits of the drug outweigh any risks. 

If you notice any of the following, contact your doctor or healthcare provider to discuss what you’re experiencing:

• Increased feelings of agitation or irritability 
• Feelings of anxiety to the point of a panic attack
• Insomnia or other sleep disturbances
• Change in mood, mood swings
• Increased thoughts of suicide or suicidal behavior — more common in children, adolescents, and young adults

Angle-closure glaucoma

Angle-closure glaucoma is a serious eye condition in which a blockage causes a sudden increase in eye pressure. It’s listed as a very rare but possible side effect of Wellbutrin. If you have a history of eye conditions or if you start to experience any changes to your vision after taking Wellbutrin, talk to your doctor immediately for medical advice. 

Symptoms of angle-closure glaucoma can include:

• Severe eye pain
• Blurred vision
• Headache
• Nausea
• Seeing halos around lights

How Long Do Wellbutrin Side Effects Last?

How long Wellbutrin side effects last will vary from person to person. Many — like insomnia, nausea, and headache — resolve within a few days to weeks as your body adjusts to your antidepressant medication. 

How to Manage Wellbutrin Side Effects

Managing Wellbutrin’s side effects starts with discussing anything uncomfortable or concerning with your doctor. They’ll be able to assess what you’re experiencing and, if needed, adjust your dosage or make other changes to your treatment plan. 

In the meantime, some ways you can manage Wellbutrin side effects include:

• Take your medication with food if it upsets your stomach
• Drink plenty of water, especially if dry mouth is a side effect
• Reduce your caffeine intake
• Maintain a healthy and consistent sleep habit
• Exercise
• Take Wellbutrin earlier in the day if you experience insomnia
• Monitor your mood and contact your doctor if you notice extreme mood swings
• Avoid alcohol and recreational drugs 

“When taking Wellbutrin XL or XR, one should be mindful of the potential for increased anxiety or agitation, particularly in those who struggle with pre-existing anxiety disorders. If you experience these side effects, it’s crucial to communicate them to your psychiatrist. They may adjust your dosage or prescribe additional medications to help mitigate these symptoms while still benefiting from Wellbutrin.”

– Talkspace therapist Bisma Anwar, LPC, LMHC

See If Wellbutrin Is Right for You with Talkspace 

Wellbutrin treatment can be game-changing in helping you manage symptoms of depression. It can help you get back on track toward leading a healthy and productive life full of rewarding relationships and a new outlook. 

Talkspace can be the first step in taking control of your mental health. Our licensed, experienced mental health professionals are there when you need them, whether that means you’re seeking therapy or need help with diagnosis, prescriptions, or medication management.

Contact Talkspace today to start the process and get Wellbutrin prescribed by an online psychiatrist.

Why Does Wellbutrin Affect Weight?

Research shows that Wellbutrin is different from most antidepressants. Many people who take it find that weight loss is more common than weight gain. We don’t fully understand how or why Wellbutrin (or other antidepressants) work, but it’s widely accepted their efficacy is related to their ability to alter the levels of certain neurotransmitters in the brain that affect things like mood, sleep, and emotion regulation. There are several reasons Wellbutrin weight gain might be less common in most people and why weight loss occurs.

Appetite suppression

Wellbutrin works by altering levels of dopamine and norepinephrine in the brain. Both of these neurotransmitters play a role in appetite regulation. Unlike other antidepressant medications, Wellbutrin can cause a decrease in appetite, which can lead to weight loss.

Metabolic rate increase

Wellbutrin can have a stimulant effect on the central nervous system, increasing metabolic rate and allowing some people to burn calories faster. As a result, it’s common to experience weight loss or have difficulty gaining weight when taking Wellbutrin.

Energy level boost

Because it has stimulant properties, Wellbutrin can cause an uptick in energy that might lead to increased physical activity. As a result of being more active, weight loss is possible when taking this antidepressant medication.

“The boost in energy level can lead to more physical activity. This can directly contribute to weight loss.”

– Talkspace psychiatrist Dr. Dion Metzger, MD

Reduction in cravings

Wellbutrin is sometimes prescribed for smoking cessation because it can reduce cravings. It’s believed that the same is true for food cravings. By altering the levels of dopamine and norepinephrine in the brain, Wellbutrin can regulate reward pathways linked to cravings. When the cravings subside, you may eat less, resulting in weight loss. 

Neurotransmitter effects

Wellbutrin prevents the reuptake of dopamine and norepinephrine. Because the neurotransmitters aren’t reabsorbed as quickly, higher levels remain in the brain, offering benefits like added fatty acids into the bloodstream and improved mood, motivation, and metabolism. Since it’s also known to reduce cravings and suppress appetite, weight loss is possible in some people.

“Norepinephrine increases the rate of fat loss by releasing fatty acids into the bloodstream. This reduction of fat contributes to weight loss. Dopamine works directly with appetite. There is a connection between low dopamine levels and overeating. A dopamine boost can prevent the urge for increased food intake.”

– Talkspace psychiatrist Dr. Dion Metzger, MD

How Fast Does Weight Loss Occur on Wellbutrin?

In one study, almost 70% of participants saw weight loss of more than 5% of their body weight in 8 to 24 weeks — most of which came from lost body fat. A clinical trial found that participants who lost 5% or more of their body weight within 16 weeks and stayed on Wellbutrin for a year or longer were more likely to keep that weight off. 

Another study looked at the effects of Wellbutrin weight loss when the drug was taken in combination with nutrition counseling and exercise. Researchers found that some clinically obese adults were able to lose between 7 and 10% of their body weight over 24 weeks. 

It’s important to note that Wellbutrin is not FDA-approved as a weight loss medication, although the drug is sometimes prescribed off-label to help. Also worth noting is that not everyone who takes Wellbutrin will lose weight. 

Factors that can impact weight loss on Wellbutrin include:

• Dosage
• Metabolism
• Lifestyle
• Weight when starting the medication
• Dosage adherence

If you’re taking Wellbutrin and have questions about weight loss or weight gain, openly discuss your questions or concerns with your family physician. Be sure to let a healthcare professional know if you have a rapid or unexplained change in weight — more than 10 pounds in 4 – 6 weeks — or if your weight change is persistent over time. 

A doctor or mental health professional can offer personal, holistic medical advice that considers everything. Monitoring your progress allows them to make necessary adjustments to your treatment plan where and when needed.   

How to Manage Weight Changes While on Wellbutrin

Monitoring weight on Wellbutrin takes a well-defined plan that combines a healthy lifestyle, nutrition, and mindfulness. Manage Wellbutrin weight loss by keeping the following in mind. 

Monitor eating habits

Being mindful of your portion sizes and eating regular, consistent meals will help stabilize your metabolism and make maintaining weight easier. Monitoring your eating practices enables you to identify problematic habits that may contribute to a weight change — whether you’re eating too little or too much. 

Healthy diet 

A healthy diet is vital to maintaining a healthy weight for your body size and type. Focus on eating a balanced diet rich in fruits, vegetables, lean proteins, whole grains, and healthy fats. Limit how much processed food you eat and avoid foods high in refined sugar, carbohydrates, and saturated fats. 

Regular exercise

Studies show that working out regularly is great for establishing a healthy weight long-term. It’s also a proven way to improve mood, according to research. 

Consult a dietician

If you’re struggling with your weight or with making healthy lifestyle and diet changes, consider working with a dietician. They can offer expert advice and help you make beneficial changes to your diet and lifestyle that will promote weight loss.  

Mindful eating

Mindfulness simply means being aware of what you’re doing in the present. It’s an effective form of meditation that offers positive results, including weight loss. Paying attention to what — and how much — you’re eating can be a game changer in your weight loss journey. Mindfulness eating teaches you to become aware of thoughts and behaviors that are associated with eating by focusing on sensory aspects as you eat. 

Practicing mindfulness will help you learn to:

• Eat with awareness
• Pay attention to sensations like flavors, textures, and smells of foods
• Listen to your own hunger and fullness cues
• Savor what you’re eating so you can slow down
• Be present at your meals so you can begin practicing a philosophy of eating to live instead of living to eat 
• Recognize if you’re an emotional eater

Talk to a Psychiatrist About Wellbutrin Side Effects

Wellbutrin is different from most antidepressants in that it’s more likely to cause weight loss than weight gain. With any drug, it’s essential to find the right balance between the benefits it offers and the risk of potential adverse effects. Finding optimal mental and physical health should always be the ultimate goal. You can determine with your healthcare provider if Wellbutrin might help you get there.

“Wellbutrin is one of the top medication choices for patients concerned about weight gain. The likelihood of weight gain with this medication is very low. If a weight change is seen, it is more likely to be weight loss. If you have lost more than 10 lbs. over a 4 – 6 weeks period (without change in diet or increase in exercise), consult your healthcare provider. Rapid weight loss is never ideal for the body.”

– Talkspace psychiatrist Dr. Dion Metzger, MD

Talkspace helps you get the mental health guidance and support you need, along with prescriptions and medication management when needed. Talkspace psychiatrists are licensed and trained to help you find the most effective treatment plan to address your mental health needs. 

The best way to achieve a healthy mind and body is through a personalized approach that looks at you as a whole person. Talkspace can offer you everything you need to take control of your depression — or any other condition, including managing Wellbutrin weight loss — in a healthy way.

Connect with an online psychiatrist at Talkspace today to discuss a Wellbutrin prescription.

What is Wellbutrin?

Wellbutrin is an FDA-approved atypical antidepressant medication that’s used to treat some types of depression and help with smoking cessation. It’s also sometimes prescribed off-label — that is, not FDA-approved for the use of, but has been found to help — to treat symptoms of attention-deficit hyperactivity disorder (ADHD) and other mental health conditions. 

Wellbutrin treatment is thought to work by stopping the transport of the neurotransmitters dopamine and norepinephrine back into nerve cells, effectively boosting levels in the brain to improve mood, motivation, stress response, and other things related to depressive symptoms. 

Wellbutrin Uses

Wellbutrin comes in two forms — Wellbutrin XL (extended-release, which also comes in the generic bupropion XL) and Wellbutrin SR (sustained-release, also available via bupropion SR). Although they work the same way and have the same active ingredient, Wellbutrin XL differs in that it’s an extended-release drug that’s released into the body more slowly and stays in your system longer. Follow the medical advice of your psychiatrist or healthcare provider to determine which form of Wellbutrin treatment you should take.

Wellbutrin uses include:

• Wellbutrin XL: Treats depression and can help prevent seasonal affective disorder.
• Wellbutrin SR: Treats depression and can help some people quit smoking by reducing nicotine withdrawal symptoms. 

Depression

Wellbutrin increases dopamine and norepinephrine levels in the brain by preventing reabsorption. When levels of these neurotransmitters stay elevated, they can effectively reduce or relieve symptoms of depression. There is much research that supports the efficacy of Wellbutrin in treating major depressive disorder (MDD). One meta-analysis found that the drug was effective in reducing depression scores in 24 out of 27 trials. 

Depression symptoms often include: 

• Feelings of persistent sadness
• Loss of interest in things once found pleasurable
• Change in appetite 
• Change in sleep patterns
• Feelings of worthlessness or guilt
• Having difficulty concentrating or making decisions 

Seasonal affective disorder

Seasonal affective disorder (SAD) is a type of depression that comes with the changing of the seasons. It can cause a seasonal pattern marked by lack of energy, change in appetite, weight gain, excessive sleeping, and loss of interest in activities once enjoyed. 

In studies, when started in the fall, Wellbutrin XL was found effective in preventing recurrent symptoms related to SAD. Though symptoms can (and often do) resolve on their own in the spring and summer months, people who have an intense experience might benefit from a drug like Wellbutrin. 

Off-label uses might include:

• Anxiety
• Sexual dysfunction
• Fatigue
• Some anxiety disorders — like PTSD and social anxiety disorder
• Attention-deficit hyperactivity disorder (ADHD)

Pros & Cons of Wellbutrin

Pros of Wellbutrin	Cons of Wellbutrin
Effective antidepressant	Potential side effects include dry mouth, headache, insomnia, nausea, agitation
Can be effective in people who don’t see improvement in depression symptoms with other classes of drugs	May increase blood pressure
Low risk of weight gain from Wellbutrin	Must be dosed carefully to reduce the risk of some side effects, like seizures
Negative sexual side effects are less common	Not suitable for people with a history of seizures, eating disorders, and some psychiatric conditions
Might help reduce cravings and withdrawal symptoms in people who are quitting smoking	Can take several weeks before seeing/feeling the full effects

Side Effects of Wellbutrin

Like any drug, Wellbutrin has the risk of side effects. In general, studies show that Wellbutrin is well-tolerated, with low rates of sexual dysfunction and the possibility for weight loss instead of weight gain (which is a potential side effect of most other antidepressants). Not everyone will experience these Wellbutrin side effects, but it’s important to know what to look for if you start taking this drug. If you begin to experience side effects not listed on the boxed warning label, reach out to a medical professional. 

Some potential side effects of Wellbutrin include: 

• Dry mouth
• Headache
• Insomnia
• Nausea
• Agitation
• Constipation
• Dizziness
• Sweating
• Increased heart rate
• Tremor
• Blurred vision
• Loss of appetite
• Weight loss
• Anxiety
• Irritability
• Seizures (rare but can be more common at higher doses)
• High blood pressure (especially at higher doses or for someone with preexisting hypertension)

Wellbutrin Dosage

Optimal Wellbutrin dosage will vary from person to person depending on factors like age, weight, the condition being treated, other conditions and medications, family history, and more. 

You should always discuss dosage with your doctor to ensure you take the appropriate amount for your symptoms and condition. 

Take Wellbutrin exactly as directed. Do not chew, crush, or break Wellbutrin extended-release tablets — they should always be swallowed whole. 

Forms

Wellbutrin comes in multiple forms – tablets are available in:

• Sustained-release (SR)
• Extended-release (XL)

Dosage

Dose will depend on the condition being treated and symptom severity, among other things. 

• Major depressive disorder (MDD): The starting dose is usually 100 – 150 mg 1 – 2 times daily. After a few days, your doctor might increase your dose to 3 times per day. The maximum dose is 300 – 450 mg daily, depending on which form your doctor prescribes.
• Seasonal affective disorder: The starting dose is generally 150 mg per day. After a week (7 days), your dose may be increased to 300 mg once per day. Treatment often begins in the fall, before symptoms start, and is typically discontinued in the early spring.

Additional Considerations

Beyond dosing considerations, there are other factors to keep in mind if you’re planning to take Wellbutrin for depression. For example, you should try to take this medication at or around the same time daily. This ensures a stable and consistent level of the drug in your bloodstream, maximizing efficacy. 

You can take Wellbutrin with or without food, but you should avoid alcohol as it can increase the risk of seizures or other side effects. 

Interactions

All drugs have the risk of interacting with other medications. For this reason, it’s essential to inform your doctor of anything else you’re taking besides Wellbutrin. This includes natural or over-the-counter (OTC) supplements or vitamins. 

Drugs known to interact with Wellbutrin include:

• Selective serotonin reuptake inhibitors (SSRIs) 
• Serotonin-norepinephrine reuptake inhibitors (SNRIs)
• Monoamine oxidase inhibitors (MAOIs)
• Tricyclic antidepressants (TCAs)
• Antipsychotic medications
• Anticonvulsant medications
• Nicotine replacement therapy (NRT)
• Alcohol

Warnings

Wellbutrin can increase your risk for serious health conditions. Warnings when taking this drug can include, but aren’t limited to, the following:

• Increased risk of seizure
• Psychiatric symptoms, like an increase in suicidal thoughts and behaviors
• Neuropsychiatric events, such as hallucinations, increased agitation, paranoia, delusional thinking, and mania in some people
• Hypertension 
• Allergic reactions — while rare, cases of angioedema (extreme swelling) and anaphylaxis (a severe, potentially life-threatening allergic reaction) have been reported in some people who take Wellbutrin

“Wellbutrin is not to be taken in a patient with a history of seizures. If taken, it increases the likelihood of them having another seizure.”

– Talkspace psychiatrist Dr. Dion Metzger, MD

Selective serotonin reuptake inhibitors (SSRIs)

Selective serotonin reuptake inhibitors (SSRIs) are considered the gold standard treatment for depression. They improve mood and emotion by upping serotonin levels in the brain. SSRIs are often the first type of drug that’s tried because they’re generally well-tolerated and have fewer side effects than some other types of antidepressants. 

Serotonin-norepinephrine reuptake inhibitors (SNRIs)

Serotonin-norepinephrine reuptake inhibitors (SNRIs) block the reabsorption of both serotonin and norepinephrine in the brain. These neurotransmitters are important in mood regulation, memory, and the sleep-wake cycle. 

Tricyclic antidepressants (TCAs)

Tricyclic antidepressants (TCAs) are an older class of drugs and typically are only suggested if SSRIs and SNRIs haven’t reduced depression symptoms. TCAs were initially developed for psychotic episodes but were later found to effectively treat depression in some people. 

Atypical antidepressants

If Wellbutrin (which is also an atypical antidepressant) doesn’t seem to be working, your doctor may decide to start you on a different medication in this same class. Some other atypical antidepressants can be an excellent alternative to Wellbutrin.

“An alternative to Wellbutrin is an SNRI (Serotonin and Norephrine Reuptake Inhibitor) such as Pristiq or Effexor XR. SNRI’s can boost the neurotransmitter norepinephrine to help with concentration and energy, similarly to Wellbutrin’s benefits.”

– Talkspace psychiatrist Dr. Dion Metzger, MD

Get Wellbutrin Prescribed Online

Before you can get a prescription for Wellbutrin online, you’ll need a diagnosis from a licensed doctor or mental health provider like a psychiatrist. Talkspace offers convenient, affordable, and easily accessible online therapy and medication consultations, prescriptions, and management. 

Talkspace is a reliable resource for all your mental health needs. You’ll be connected with a qualified professional who’s experienced and ready to help. 

You don’t have to live in the grips of depression or another mental health condition. Talkspace can help you with therapy and, if needed, medication so you can take charge of your mental health and get back to living a healthy, happy, productive life. 

Connect with an online psychiatrist about Wellbutrin today. 

What is the Difference Between Therapy and Medication?

Therapy involves engaging with a mental health professional to explore and modify thought and behavior patterns, while medication focuses on altering brain chemistry to address mental health conditions. Research shows that when it comes to talk therapy vs medication, both can be effective, but the type of mental health condition you have and other factors will determine what “the best” treatment option is. Here’s how both treatment methods work:

• Therapy, also known as psychotherapy or talk therapy, is a process in which you work with a trained, licensed mental health professional to explore thought and behavior patterns that contribute to mental health concerns. There are dozens of types of therapy, and which one will be most effective for you depends on your condition, symptoms, goals for recovery, and personal preference. 

• Medication is often used alone or in a combined treatment with therapy and/or self-help techniques to treat mental health conditions like anxiety, depression, obsessive-compulsive disorder (OCD), and countless other things. Most common mental health medications work by altering brain chemistry and neurotransmitters related to mood and thought process. For example, medication for depression can work by altering levels of dopamine or serotonin in the brain — both play a role in things like pleasure and positive mood.

Benefits of Therapy

Therapy offers several benefits and can address the underlying causes of mental health conditions. It’s a holistic approach that teaches coping strategies, helps you identify and change unhealthy and unhelpful thoughts and behaviors, and promotes self-awareness. The process relies heavily on personal growth. It’s hard work, but those willing to put in the time will see the rewards. 

Benefits of therapy include:

• Identifying and exploring underlying issues
• Learning helpful coping strategies for the future
• Improving self-awareness 
• Developing the ability to recognize early warning signs in a safe, non-judgmental place
• Building emotional resilience and regulation
• Instilling confidence and the ability to make healthy changes

“Therapy can be incredibly helpful in learning to manage the symptoms of a person’s mental health struggles. It allows for a safe space to work through thoughts and emotions without judgment. Through therapy, coping strategies that work for a client can be found and implemented. No one coping skill will fit all people. Working with a mental health professional helps a client find that tailored approach in managing their mental health issues.”

– Talkspace therapist Minkyung Chung, MS, LMHC

Benefits of Medication

For some people, medication is a crucial component of a comprehensive mental health treatment plan. Certain types of medication offer significant benefits for stabilizing or improving symptoms. Mental health medication can provide relief for severe conditions that don’t respond to therapy or therapy alone isn’t enough.

Benefits of medication include:

• Symptom relief/symptom reduction
• Stabilizing severe conditions
• Complementing psychotherapy
• Improving quality of life

Therapy vs. Medication for Different Mental Health Conditions

When trying to compare mental health drugs vs. therapy, the type of condition being treated will always play a role. For some conditions, therapy might be more effective, whereas, for others, psychiatric medication can be critical in offering more immediate, short-term relief for symptoms that therapy hasn’t been able to address. In many instances, a combined approach will offer the most optimal results.

For anxiety

According to recent research, more than 40 million adults in the United States have at least one type of anxiety. Fortunately, this is a highly treatable condition. With the right anxiety treatment plan, many people can find relief from symptoms and live a healthy, happy, productive life. 

• Therapy for anxiety disorders: There are several effective types of therapy for anxiety. Cognitive behavioral therapy (CBT) and exposure therapy are popular options. Both help you learn to manage symptoms by challenging unhealthy or irrational thoughts and understanding what sets you off so you can avoid or learn to cope with it.

• Medication for anxiety disorders: There are multiple options for anxiety medication. Selective serotonin reuptake inhibitors (SSRIs) are technically an antidepressant, but they’re often a first-line treatment for anxiety. Serotonin and norepinephrine reuptake inhibitors (SNRIs) can also help with symptoms of anxiety. SSRIs and SNRIs can both be used long-term to treat anxiety, but other drugs, like benzodiazepines or “benzos,” might be prescribed for short-term use. If you aren’t sure, consider these signs you might need anxiety medication.

For depression

Major depressive disorder (MDD) is a common mental health condition that impacts more than an estimated 8% of adults in the U.S. In studies, therapy is proven effective in treating symptoms of depression. Research shows that medication efficacy is related to the severity of symptoms — that is, the more severe depressive episodes and symptoms are, the more likely the psychiatric medication is to work. 

• Therapy for depression: Common forms of therapy for depression treatment include cognitive behavioral therapy (CBT), interpersonal therapy (IPT), and mindfulness-based therapy. Therapy can improve depression symptoms by helping you spot negative thought patterns, improve self-awareness, and offer practical coping tools. 

• Medication for depression: Antidepressants like selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) can help regulate levels in the brain to improve mood. Other depression medications include monoamine oxidase inhibitors and tricyclic antidepressants (TCAs).

For attention-deficit/hyperactivity disorder (ADHD)

Attention-deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder that can cause inattentiveness and/or excessive movement and activity in some people. 

• Therapy for ADHD: ADHD therapy helps people learn to manage symptoms so they can lead rewarding, productive lives. Many types of therapy can effectively treat ADHD, including CBT, mindfulness-based therapy, occupational therapy, and play, art, or music therapy. 

• Medication for ADHD: Both stimulants and non-stimulants can treat symptoms of ADHD. Sometimes, an antidepressant might be used off-label. Which ADHD medication is best for someone will depend on several factors, like comorbid conditions, symptom severity, health history, and more. 

For bipolar disorder

Bipolar disorder was once referred to as manic depression or manic depressive disorder. It causes extreme highs (mania) and dark lows (depressive episodes) that can be debilitating if not treated effectively.

• Therapy for bipolar disorder: Effective forms of therapy to treat bipolar disorder can include psychoeducation, cognitive behavioral therapy (CBT), and family therapy.

• Medication for bipolar disorder: Medication is commonly used in combination with therapy to treat bipolar disorder. Mood stabilizers like lithium are the first line of treatment when treating bipolar disorder. Antidepressants or antipsychotics can also be prescribed as bipolar medication when mood stabilizers alone aren’t effective.

For obsessive-compulsive disorder (OCD)

Obsessive-compulsive disorder (OCD) is a type of anxiety disorder that causes unwanted or unwarranted repetitive thoughts (obsessions) that can lead to unhealthy, uncontrollable behaviors (compulsions). OCD can negatively impact life, relationships, and the ability to function. Though not curable, effective treatment options are available. 

• Therapy for OCD: Many types of therapy can alleviate symptoms of OCD — CBT, exposure and response therapy (ERP), and psychodynamic therapy are some of the best types of therapy for OCD. 

• Medication for OCD: Some medications used to treat OCD are antidepressants in the class of drugs known as selective serotonin reuptake inhibitors (SSRIs) and some off-label drugs if SSRIs aren’t effective. 

For post-traumatic stress disorder (PTSD)

Post-traumatic stress disorder (PTSD) is a condition some people develop after experiencing or witnessing extreme trauma. Not everyone who goes through a traumatic event will develop PTSD, but for those who do, treatment is essential. 

• Therapy for PTSD: Several types of therapy can help people manage PTSD symptoms. Trauma-focused therapies, like prolonged exposure therapy, EMDR therapy, and cognitive processing therapy, can be effective ways to treat PTSD naturally.

• Medication for PTSD: Medication is used to treat PTSD in some people. Antidepressants in the class of drugs known as selective serotonin reuptake inhibitors (SSRIs) can reduce or relieve symptoms of PTSD. Other types of PTSD medication that can be effective include anti-anxiety medications, Alpha-1 blockers, and mood stabilizers. Medication tends to work most effectively when combined with therapy.

For schizophrenia

Schizophrenia is a neuropsychiatric disorder that affects less than 1% of people in the United States. It’s characterized by hallucinations, difficulty thinking, disorganized speech, paranoia, and delusions. While there’s no cure for schizophrenia, psychological treatments and antipsychotic medications can be incredibly beneficial in reducing symptoms.

• Therapy for schizophrenia: Certain types of therapy will help reduce symptoms of schizophrenia. Therapy for schizophrenia focuses on reducing stress, enhancing function, and improving social skills. Some of the therapies that are effective in treating schizophrenia include CBT, art therapy, and family therapy.  

• Medication for schizophrenia: Schizophrenia can be successfully treated by schizophrenia medication in many people. Antipsychotics — both atypical and typical — can reduce symptoms and lessen the potential for future episodes.

For personality disorders

Personality disorders are conditions that cause patterns of unhealthy thought processes and behaviors that differ from what’s expected — people with personality disorders will have difficulty in at least 2 of the following areas:

• How they think about themself
• How they think about others
• How they respond emotionally
• How they relate to others
• How they behave

There are many types of personality disorders, including:

• Antisocial personality disorder
• Avoidant personality disorder
• Borderline personality disorder
• Dependent personality disorder
• Histrionic personality disorder
• Narcissistic personality disorder
• Obsessive-compulsive personality disorder
• Paranoid personality disorder
• Schizoid personality disorder
• Schizotypal personality disorder

Therapy for personality disorders: Some types of therapy are more effective than others in treating personality disorders. Commonly used therapy modalities include cognitive behavioral therapy (CBT), dialectical behavior therapy (DBT), group therapy, and psychoeducation.

Medication for personality disorders: There isn’t one medication that treats all personality disorders. Sometimes, depending on symptoms and type of disorder, antidepressants or anti-anxiety medication might be prescribed. Mood stabilizers can also be effective in some cases.

How Does Medication & Therapy Work Together?

Medication and therapy can be combined to offer the most support. Medication can stabilize mood and provide rapid relief when needed. Therapy helps address underlying issues and enhance self-awareness. A combined approach may maximize outcomes and improve overall mental well-being.

Is Therapy Better Than Medication?

What works best for you will depend on multiple factors, including diagnosis, personal preference, other health conditions, and more. Some research suggests that when it comes to cognitive behavioral therapy vs medication, CBT might be more effective in people with anxiety, whereas depression might be better treated with a combined approach that uses both therapy and drugs. 

Ultimately, the right treatment plan will be as unique as you are, and you’ll work with your therapist or doctor to determine the best path forward.

Considerations for Choosing Therapy vs. Medication

Before deciding whether psychotherapy vs. medication is the right option, you should talk to your provider. 

Considerations to take into account include:

• Type of mental health condition
• Severity of symptoms
• Your lifestyle 
• Your comfort level and personal preference for treatment
• Financial considerations 
• Your insurance situation
• Benefits and risks of each option
• Your previous treatment history 

“There is no right or wrong answer when it comes to choosing therapy or medication. It’s important to consider that both options are available to a client. Historically, therapy and medication have worked hand in hand to help a client manage their mental health struggles. So, one is not always better than the other. With certain mental health disorders, medication management may be necessary before therapy can begin but medication alone shouldn’t be the answer.”

– Talkspace therapist Minkyung Chung, MS, LMHC

Start Comprehensive Mental Health Treatment

Prioritizing your mental health is essential, especially when you’re struggling in life. Therapy can offer you the tools you need to manage your mental health, and a provider can help you decide if medication might be beneficial. The right treatment plan will offer coping mechanisms and the best way to move forward in your life in the healthiest, happiest, most positive way.

Talkspace offers online therapy and online psychiatry services that make getting mental health help simple and affordable. The online platform means you can access therapy wherever you are, so therapy is convenient and effective. Talkspace offers comprehensive care with therapy and medication management that will put you on the path toward healing. 

Reach out today to get mental health treatment with therapy and medication. 

Average Timeline for Onset of Action

The big question before starting a drug is usually how long it takes to work. Mood improvement, along with reduced severity and frequency of mood swings, can be experienced as soon as the first few weeks of taking Lamictal, but it may take months in some people.  

According to research, Lamictal often begins working effectively within several weeks of starting it, although dosage adjustment is common with this drug. It’s vital to increase Lamictal dosage slowly to prevent certain adverse side effects of Lamictal. 

Initial Lamictal response: Many people notice small changes in their mood disorder symptoms soon after starting Lamictal. For example, mood stabilization improvement can be experienced relatively quickly — often in just a few weeks.  

Stabilization response to Lamictal: It might take months before you experience the full results of a mood stabilizer medication like Lamictal. Knowing this can help set your expectations and reduce frustration if the drug doesn’t immediately offer you the best outcome. 

Factors Affecting How Quickly Lamictal Works

Keep in mind that medications won’t always work exactly the same for everyone, and individual experiences can vary. 

Research suggests that triazine anticonvulsants like Lamictal work by binding voltage-gated sodium channels to inhibit the release of glutamate (a neurotransmitter). This might stabilize brain activity and prevent mood disorder symptoms like mood swings and depressive episodes. 

Several factors can affect how quickly Lamictal works. 

Dosage adjustments

With a drug like Lamictal, dosage adjustments are necessary, especially in the beginning. It can be frustrating when medication doesn’t immediately work exactly as you had hoped, but be patient as you work with your doctor to get the right dose for optimal results. Be sure to take the Lamictal or lamotrigine dose exactly as directed and talk to your doctor along the way. 

“Lamictal requires a slow dose titration to reduce the chances of developing a skin rash. The dose should not be increased faster than recommended by the mental health provider. It may take several weeks to months to provide the optimal mood stabilization.”

 – Talkspace psychiatrist Dr. Dion Metzger

Individual factors

Individual factors like body chemistry, weight, age, severity of symptoms, and more can impact how well a drug works and how long it takes to be effective. Because we all have unique body chemistry, medications can metabolize differently in each of us. For some, a Lamictal or lamotrigine dose will work quickly. For others, it can take more time. 

Interaction with other certain medications

It’s crucial to let your doctor know about every medication, vitamin, and supplement you take before beginning a new drug, and this is also important when taking Lamictal. Some drug interactions with certain medications can affect Lamictal’s efficacy and how quickly it’s absorbed in the body. Even drug interactions with common or over-the-counter medications — like some cough syrups, folic acid, or hormonal birth control contraceptives — can have adverse effects on Lamictal. 

How Do You Know if Lamictal is Working?

If you’re wondering how long it takes for Lamotrigine to work, you’re probably also wondering how to tell if the drug is actually working at all. 

If Lamictal is effective for you, you might feel like you have a better outlook on life, you’re able to control your stress better, or you’re less reactive to situations. 

Additional signs Lamictal is working for you might include things such as:

• Your daily functioning improves
• You have an enhanced quality of life
• You’re sleeping better
• You have more (and stable) energy throughout your days
• You can focus on tasks better
• You see improvement in personal relationships 
• Your work or school performance improve
• You start to have longer intervals between depressive episodes

One of Lamictal’s biggest benefits is that it can delay occurrences. This means if it works for you, you might experience a noticeable decrease in the frequency of depressive episodes. 

What to Do When Lamictal is Not Working

Talk to your doctor if you’re concerned that Lamictal isn’t working for you. Before completely giving up or deciding you want to change bipolar disorder medication, your doctor will likely first adjust your dosage. 

Dosage adjustment

Your doctor might reevaluate your dosage if they feel you’ve been on your current dose long enough to expect noticeable improvement. Remember that it can take time for your body to adjust to a new dosage, so you might need to wait several weeks (or even months) before you know if a new treatment plan is working.

“It is not recommended to quit Lamictal suddenly. This is because restarting the medication later may increase the risk of skin rash. A restart of Lamictal would require returning to the starting dose if it has been 5 days or more since stopping the medication. If considering discontinuing Lamictal, always discuss it with your mental health provider first. The discontinuation of Lamictal takes at least 2 weeks of lowering the dose until stopping completely.”Dr. Dion Metzger

Therapy

A combined approach that includes both medication and therapy for bipolar disorder is typically most effective for treatment. Talk therapy (also known as psychotherapy) can help prevent relapse into depression. In fact, one study found that people who engage in group psychoeducation are over two times more likely to not have a relapse compared to the placebo group. 

Another meta-analysis found that cognitive behavioral therapy (CBT) and interpersonal therapy are linked to depressive symptom stabilization in people living with bipolar. The study also concluded that combining pharmacotherapy (using drugs) with traditional skills-based therapy and intervention is beneficial in treating bipolar disorder. 

Explore alternative drugs

Some medications just don’t work for everyone. If your doctor has tried adjusting your dosage, but Lamictal still doesn’t seem to be working as well as you want, it might be time to explore other drug options. There are many types of medications used to treat bipolar depression, so don’t give up hope if Lamictal doesn’t seem effective.

Consider weighing the pros and cons of Lamictal vs. Lithium.

Make lifestyle adjustments

Lifestyle changes are simple to implement and can benefit your physical and mental health. Working out, eating healthy, getting enough sleep, and learning and using stress-coping tools can all play an essential role in maintaining optimal mental health. Results can be drastically improved when you combine a healthy lifestyle with medication.  

Get Personalized Mental Health Treatment with Talkspace

You don’t have to feel overwhelmed about trying to find the right bipolar disorder treatment. Talkspace makes the journey toward customized mental wellness easy, convenient, and affordable. With Talkspace, you can get tailored therapy and medication management help to treat bipolar disorder symptoms, all from the comfort of your home.

If you’re ready to explore options to treat your bipolar disorder, Talkspace can be a valuable resource. Reach out to Talkspace today to learn more about seeing a psychiatric provider and getting prescribed Lamictal online. 

Understanding Lamictal vs Lithium

Lamictal and Lithium stand out as two commonly prescribed options to treat symptoms of bipolar disorder. Each has a unique mechanism of action and benefits, but how a drug works for one person might not be how it works for another. Exploring the differences between Lithium and Lamictal can help you discuss which one to try with your healthcare provider.

Lamictal

Lithium is in the class of triazine anticonvulsants and is believed to work by stabilizing electrical activity in the brain to prevent or reduce mood swings. 

Some research suggests that Lamictal acts on serotonin reuptake, which can offer antidepressant effects. Lamictal is more effective in treating depressive symptoms of bipolar than it is in treating manic symptoms.  

FDA-approved uses for Lamictal

The Food and Drug Administration (FDA) approved Lamictal to treat epilepsy as well as bipolar disorder. 

Benefits of Lamictal

Lamictal reduces the risk of bipolar depressive episode relapse by delaying mood changes. Prevention is probably its most significant benefit, and it’s also one of the only drugs that treat bipolar by lifting depressive symptoms instead of suppressing mania. 

Lamictal is more widely used to treat the depressive side of bipolar and might not be the best option for those with active hypomania or mania. A significant upside to Lamictal mood stabilizers is it’s well-tolerated. 

Lithium

Lithium is a mood stabilizer that treats bipolar disorder symptoms by regulating sodium transport that affects mania. It’s believed that Lithium is effective because it can reduce inflammation in the brain. Lithium is known to regulate mood swings and manic episodes to minimize aggression, poor judgment, hyperactivity, and the feeling that you don’t need sleep.  

FDA-approved uses for Lithium

The Food and Drug Administration (FDA) approved Lithium to treat bipolar disorder symptoms, including acute manic and mixed episodes, as well as maintenance in people seven years and up. 

Benefits of Lithium

Benefits of Lithium include the ability to reduce manic symptoms of bipolar disorder. Some research shows Lithium might be the only drug that’s effective in preventing mood, depressive, and manic episodes. It’s also shown to reduce suicide risk in some people.  

“Lamictal is one of the best-tolerated mood stabilizers with little weight gain and is often used for bipolar depression. Lithium is best for bipolar mania and specifically decreasing suicidal thoughts. Lithium is often underutilized because of Lithium’s side effects that include weight gain, tremors, and possible effects on the thyroid.”

– Talkspace psychiatrist Dr. Dion Metzger

Brand Name	Lithium	Lamictal
Generic Name	Lithium carbonate	Lamotrigine
Uses — FDA Approved	Bipolar disorder – manic episodes Long-term bipolar maintenance	Bipolar disorder Seizure disorders
Off-label Uses	Major depressive disorder (as adjunct therapy) Bipolar without mania Neutropenia Vascular headaches	Unipolar depression (a major depressive episode)
Side Effects	Diarrhea Nausea Dry skin Dry mouth Increased thirst Metallic taste in the mouth Mild hand tremors Drowsiness Lithium weight gain	Headache Dizziness Agitation Diarrhea Nausea or vomiting Feeling drowsy Aggression or irritability Shaking or tremors Difficulty sleeping Mild skin rash
Dosage Forms/Strengths	Forms: Capsules Tablets Oral consumption Oral syrup Compounding powder Extended-release Strength: 150mg 300mg 450mg 600mg 300mg/5L	Forms: Tablets Chewable tablets Orally disintegrating Strength: 2mg 5mg 25mg 50mg 100mg 150mg 200mg 250mg 300mg
Key considerations	Note that Lithium can impair reactions. Do not drive or use machinery until you know how Lithium will impact your reactions. Watch your sodium intake. Keep hydrated.	Avoid alcohol when taking Lamictal. Watch for serious allergic reactions, including rashes. Do not crush, chew, or break tablets.

Efficacy in Treating Bipolar Disorder

Gauging efficacy in treating bipolar disorder with Lamictal vs Lithium depends on what part of the condition you’re using medication for. In some research, both drugs were found to be superior to the placebo when assessing time to intervention for any mood episode, and studies conclude that both are effective monotherapy for bipolar II depression.  

• Manic episodes: Lithium appears to be better at preventing recurring manic or hypomanic episodes. 

• Depressive episodes: Lamictal is better at treating bipolar depression and delaying the time between episodes. 

• Maintenance: Studies suggest that Lithium is effective as the first line of treatment in acute and maintenance treatment of bipolar disorder. Additionally, Lithium is the only drug that’s shown to reduce death by suicide in people with bipolar. 

Considerations for Choosing Between the Two

Several factors can influence the decision to take Lamictal vs Lithium. 

“A discussion with a medical professional will be helpful in choosing between Lamictal and Lithium. A patient’s medical history, severity of current symptoms, and availability to have bloodwork done (necessary for Lithium) are all considered in choosing the best mood stabilizer.”

– Talkspace psychiatrist Dr. Dion Metzger

Ratings

Lamictal has a slightly higher rating (76% of Lamictal users vs 65% of Lithium users report a positive experience).  

Pre-existing health conditions

Lamictal has fewer known drug interactions (284 compared to Lithium’s 708), and there’s a striking difference with “major” interactions (9 with Lamictal vs 177 with Lithium). 

Potential side effects and limitations

While not universal, Lithium can cause weight gain in some people. Clinical trials show weight gain is even less common when taking Lamictal. Both drugs can cause difficulty focusing or concentrating and impair judgment and clear thinking. Lamictal is a Category C drug, meaning risk if used while pregnant can’t be fully ruled out. Lithium is a Category D drug, which means there’s evidence of risk when pregnant. 

Lifestyle considerations and medication adherence

You shouldn’t drink alcohol when taking either drug, as both can cause drowsiness and dizziness that could be exacerbated when drinking. Do not take more than the suggested dose of either Lamictal or Lithium — take both medications as directed by your doctor. 

Lithium blood testing

A unique aspect of Lithium treatment is the necessity for regular blood tests. These tests monitor Lithium levels in the blood to ensure they remain within a therapeutic range and check kidney and thyroid function, which Lithium can affect. 

This requirement for ongoing monitoring can influence the choice between medications, considering the added commitment and potential health implications of long-term Lithium use.

Determine if Lamictal or Lithium Is Right for You 

Only you and your doctor can decide if Lamictal or Lithium is the better option to treat bipolar disorder. If you need help determining the right course of treatment, Talkspace has licensed psychiatrists who can prescribe Lamictal or Lithium online if appropriate. Talkspace makes getting help for mental health simple, convenient, and affordable. 

Reach out today to connect with an online psychiatrist about Lamictal and Lithium.

Common Side Effects of Lamictal

You should always be aware of the side effects of Lamictal — or any drug you’re starting. 

Lamictal is a fast-acting drug used as a mood stabilizer — it peaks in the body within around 1.5 to almost 5 hours after taking it. Your doctor will likely start you on a lower dose and gradually increase the dosage every few days or weeks until you see optimal results. 

For some, finding the proper dosage can take as long as 6 weeks, at which point they may begin to feel positive results. When taking Lamictal for bipolar depression, you need to be patient, as you’ll probably need to take this drug for 6 months to prevent symptoms of bipolar depression from returning. If the medication works well, you might take it even longer. 

Lamictal’s effectiveness can last longer than 24 hours, so it’s generally used as a once-per-day dose. Because it can cause sleepiness in some people, your doctor might recommend a divided dose of Lamictal daily to reduce the risk of drowsiness. 

Other common side effects of Lamictal can include:

• Nausea or vomiting  
• Drowsiness
• Changes in blurred or double vision
• Changes in urination output
• Increased sweating
• Tightness in the chest
• Feeling more clumsy or uncoordinated than normal
• Irregular heartbeat
• Pain in the jaw
• Change in breathing pattern
• Feeling unsteady
• Discomfort in arms, back or neck
• Dilated neck veins
• Rash
• Swelling in the face, lower legs or feet, and fingers
• Weight gain

*Note this list is not all inclusive

Less Common Side Effects of Lamictal

There are also a few less common side effects of Lamictal that you should be aware of. For example, some people who start taking Lamictal experience:

• Chest pain
• Anxiety
• Rolling, uncontrollable, continuous eye movement
• Confusion 
• Increased seizures
• Depression
• Irritability
• Infection 

*Note this list is not all inclusive

Though not as common, it’s still important to tell your doctor if you have any of the side effects of Lamictal listed above. Only they can determine if a different dosage or new bipolar disorder medication might improve your symptoms with fewer side effects and adverse reactions. 

Serious Side Effects of Lamictal

Occasionally, some — though not many — people will have Lamictal (lamotrigine) side effects that are more serious. While rare, it’s important to know about the following potential side effects, as some can be life-threatening. 

Call your doctor or 911 or go to the nearest emergency room immediately if you experience the following. 

Stevens-Johnson Syndrome (SJS) & Toxic Epidermal Necrolysis (TEN)

Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare skin conditions most often caused by medications like Lamictal. 

Research found that these skin syndromes are the result of the body being unable to detoxify the drugs it sees as foreign. In response, cytotoxic T cells attack the mucosa/epidermis layer of the skin. 

Aseptic meningitis

The Food and Drug Association (FDA) notes that while Lamictal-associated aseptic meningitis isn’t common, it is a serious potential side effect that causes symptoms like fever, headache, chills, stiff neck, abnormal sensitivity to light, confusion, and more. Symptoms often occur around 16 days after starting the drug and can cause hospitalization. 

Angioedema 

Angioedema, or a hive-like swelling beneath the skin, is a noted skin reaction that an overdose of Lamictal might cause. This rare skin reaction can lead to anaphylaxis in some cases, causing severe swelling throughout the airways and lungs.

Hemophagocytic lymphohistiocytosis (HLH)

In studies, hemophagocytic lymphohistiocytosis (HLH) results from an adverse reaction to Lamictal. HLH is a very serious, almost always fatal, hyper-inflammatory condition that causes multiorgan failure. In the most severe cases, it can cause death.

If you have any of the following symptoms after taking Lamictal, you should get medical attention as soon as possible:

• Swollen lymph nodes
• Jaundice 
• Enlarged liver
• Difficulty breathing or lung issues like coughing
• Nervous system issues — headache, visual disturbance, weakness, trouble walking

Suicidal thoughts or actions

According to research, Lamictal and other antiepileptic drugs can increase the risk of suicidal thoughts or actions. If you’re experiencing increased suicidal thinking, it’s essential that you immediately reach out to your doctor or go to the nearest medical facility.  

Severe allergic reaction

Severe allergic reactions (also known as anaphylaxis) are associated with Lamictal and can cause:

• Sudden swelling of the mouth, lips, tongue, or throat
• Tightening in the throat, difficulty swallowing, and feeling of sore throat
• Difficulty breathing
• Suddenly feeling extreme confusion, dizziness, or drowsiness
• Skin or lips and tongue turning gray, blue, or pale

“In case of a fever, muscle stiffness, sore throat, dizziness, or fatigue, inform your doctor immediately.”

– Talkspace psychiatrist Dr. Muhammad Munir, MD

Multiorgan hypersensitivity reactions

Studies linked Lamictal to drug-induced delayed multiorgan hypersensitivity syndrome (DIDMOHS) in about 1 out of every 300 adults. This is a rare but potentially fatal reaction caused by some drugs. The most common symptoms are skin rash and fever. 

“In case of a rash, inform your doctor urgently, and if possible,  get it checked as soon as possible.”

– Talkspace psychiatrist Dr. Muhammad Munir, MD

How Long Do Lamictal Side Effects Last?

For the majority of people who take Lamictal, side effects are very mild and resolve within a few days to a few weeks with continued Lamictal treatment. Because Lamictal dosage needs to be gradually increased to prevent side effects, the drug can take about 6 weeks for Lamictal to fully work.

“Common side effects of nausea, headache, and upset stomach subside after a few days.”

– Talkspace psychiatrist Dr. Muhammad Munir, MD

How to Manage Lamictal Side Effects

Most Lamictal side effects, especially those that are mild, don’t require any medical attention and will go away as you adjust to taking the medication. If they’re bothering you, though, try the following to manage side effects:

• Try taking it with food if Lamictal upsets your stomach
• Take exactly as prescribed
• Stay hydrated
• Eat healthy
• Avoid alcohol and marijuana 
• Do not suddenly stop taking this medication

Talk to your doctor if side effects continue or begin to outweigh the benefits. 

“Do not stop the medication cold turkey, as that can be very dangerous, depending on the dose of the medicine.”

– Talkspace psychiatrist Dr. Muhammad Munir, MD

See If Lamictal Is Right for You with Talkspace 

Lamictal can be effective in stabilizing mood swings that are associated with bipolar disorder. Only you and your doctor can decide if a Lamictal prescription is right for you and your symptoms. 

If you’re considering starting a new medication to treat bipolar disorder, Talkspace can be your lifeline. Get paired with a licensed psychiatrist today to discuss your options for treating bipolar or any mental health condition via medication and therapy for bipolar disorder so you can get back to living. 

What is Lamictal? 

Lamictal is an FDA-approved medication used to treat seizure disorders like epilepsy along with mood disorders such as bipolar. It’s also used off-label — meaning the FDA hasn’t approved it but may effectively treat — unipolar depression (also known as a major depressive episode). 

Lamictal for bipolar disorder can be a critical part of your comprehensive treatment plan. It’s worth considering if you’re thinking about starting Lamictal treatment or changing your bipolar medication. 

How does Lamictal work?

Unfortunately, we don’t know exactly how or why Lamictal medication works to improve bipolar depression. It’s thought to impact and stabilize electrical activity in the brain, which might help prevent mood swings or delay the time between depressive mood episodes. 

Lamictal seems to be more effective in treating the depressive symptom manifestations of bipolar disorder than it is in treating mania. 

How does Lamictal make you feel?

Lamictal can decrease excitability and offer feelings of emotional steadiness. Some people experience drowsiness or sleepiness when they first start taking a Lamictal or Lamotrigine dose. These are common possible effects, and they’re generally mild, but if they’re interfering with your ability to function daily, they can often be addressed through dosage adjustment. 

For many people, Lamictal is life-changing. It can significantly reduce mood fluctuations and improve emotion control. 

Lamictal Uses

Lamictal for depression experienced with bipolar can be effective, and the prescription drug can also be used for maintenance. It’s the only mood-stabilizing drug for bipolar that works by reducing depression instead of controlling mania, making it an excellent option when depressive symptoms are more prevalent than mania. 

There are also additional off-label Lamictal uses. 

Lamictal for Bipolar I disorder maintenance

Lamictal can reduce depressive episodes associated with bipolar disorder by delaying the next occurrence. Thus, it’s the prevention aspect of this specific drug that may offer the most significant impact in controlling bipolar depression. 

Lamictal off-label for unipolar depression or chronic depression

Some recent research shows that Lamictal might be a good option for people with persistent depressive disorder (PDD) — also known as dysthymic disorder — when other antidepressants or forms of treatment haven’t helped. Other studies suggest Lamictal can significantly improve treatment-resistant unipolar depression.

Lamictal off-label for anxiety

While it’s not FDA-approved for anxiety treatment, in one study, Lamictal showed promising results in reducing stress and symptoms of chronic anxiety. More research is needed, but a Lamictal or Lamotrigine dose might be an effective off-label anxiety treatment option for some people. 

Pros & Cons of Lamictal

Like any medication, there are pros and cons to Lamictal. It’s important to use caution and understand both the benefits and the risks before you decide to take any drug.

Pros of Lamictal	Cons of Lamictal
Balances emotions	Potential for severe side effects and severe skin reactions
Generally well-tolerated by most and fast-acting	Dosage must be slowly increased to prevent risk of adverse reactions, potentially taking longer to see results
Not a high risk of weight gain	Doesn’t prevent or treat mania
Can delay time between mood change episodes	Not suggested for treating bipolar in children or adolescents

“Lamictal is an excellent choice for mood disorders, as there is no weight gain or metabolic concerns compared to other medications. It can easily be combined with other psychotropic medications like SSRIs or SNRIs to address mood, liability, agitation, and irritability.”

– Talkspace psychiatrist Dr. Muhammad Munir, MD

Side Effects of Lamictal

All drugs, including Lamictal, have a risk of severe or mild side effects. Understanding potential reactions to a new medication is important so you know what’s common, rare, or possibly life-threatening.

Common side effects of Lamictal include:

• Drowsiness
• Nausea or vomiting  
• Changes in urination output
• Tightness in the chest
• Changes in vision including blurred or double vision
• Feeling more clumsy, unsteady, or uncoordinated than normal
• Irregular heartbeat
• Increased sweating
• Pain in the jaw
• Change in breathing pattern
• Arm, back, or neck pain
• Dilated neck veins
• Rash
• Swelling in the face, lower legs or feet, and fingers

*Note this list is not all-inclusive

Less common, but still notable, mild side effects of Lamictal might include:

• Anxiety
• Depression or increased irritability
• Chest pain
• Uncontrollable or continuous eye movement
• Confusion 
• Increased seizures
• Infection 

*Note this list is not all-inclusive

Lamictal has the potential for severe, possibly life-threatening, side effects that you should be aware of: 

• Stevens-Johnson Syndrome (SJS)
• Toxic Epidermal Necrolysis (TEN)
• Hemophagocytic lymphohistiocytosis (HLH)
• Aseptic meningitis
• Multiorgan hypersensitivity reactions
• Angioedema 
• Increased thoughts of suicide
• Serious allergic reaction

Lamictal Dosage

To prevent serious side effects, Lamictal dosage needs to be slowly increased over time. Because of this, most doctors will start you on a very low dose. 

Lamictal is typically prescribed to treat bipolar depression in doses ranging from 25mg to 400mg. Your healthcare provider or doctor will likely increase your dose every 1 – 2 weeks until Lamictal works and you achieve optimal results. It can take weeks to months before you find the dosing schedule that’s most effective in treating your specific bipolar symptoms.  

There are several forms of Lamictal, including: 

• Chewable tablets
• Tablets
• Orally disintegrating
• Extended-release

How to take Lamictal

Always take Lamictal exactly as directed by your doctor or healthcare provider and use caution. Never abruptly discontinue Lamictal without discussing a safe taper plan with your doctor, medical professional, or psychiatrist first. 

Take tablets whole; do not crush them. Dissolvable tablets may be dissolved in liquid, chewed, or swallowed whole. Lamictal can be taken with or without food. 

If you forget or miss a dose of Lamictal, take it as soon as you remember, unless it’s close to the time you’d take it again. In that case, just skip the missed dose and resume with your next scheduled one. Never double-dose Lamictal. 

If you accidentally take too much Lamictal, immediately call your doctor, 911, or poison control at 800-222-1222. You can also go to your nearest emergency room. 

Additional Considerations

Lamictal can be an effective option for bipolar depression treatment, but there are some considerations to note before deciding to take this drug. 

“One has to be extra careful when starting Lamictal and adjusting the dose. It’s essential to follow the instructions and make sure not to miss the dose of the medication as that can be very detrimental to the treatment and can cause serious side effects, including having a seizure.”

– Talkspace psychiatrist Dr. Muhammad Munir, MD

Drug Interaction

Lamictal is known to interact with certain medications. To ensure Lamictal is safe for you, it’s essential to inform your doctor of everything else you take — including other prescription drugs, vitamins, and supplements, even if they’re over-the-counter. 

Lamictal can interact with more than 280 other drugs, including but not limited to:

• Adderall
• Ativan
• Ambien
• Birth control
• Gabapentin
• Ibuprofen
• Lexapro
• Metformin
• Prozac
• Xanax
• Zyrtec

*Note this drug interaction list is not all-inclusive

Warnings

Lamictal can cause serious skin reactions that may need immediate care. In some cases, they can be fatal. The likelihood of experiencing a severe Lamictal-related skin reaction increases when the dosage is too high or if there’s a rapid increase in dose. This is why ramping up the dosage must be done slowly and under diligent observation. 

Be sure to report any skin changes you notice if you’ve just started Lamictal or your doctor recently changed your dose.

Lamictal Alternatives

Although it can be quite effective in treating depressive symptoms in bipolar disorder for many people, Lamictal is not suitable for everyone. Fortunately, there are alternatives you can try if you haven’t responded well to Lamictal or if you’re experiencing adverse or intolerable side effects. 

• Depakote (divalproex sodium): Often used in bipolar disorder management, Depakote can be effective in helping to stabilize mood swings.
• Lithium: A first-line treatment for bipolar disorder, Lithium has been used for decades to help prevent both manic and depressive episodes associated with bipolar disorder. Learn how Lamictal compares to Lithium to make an informed decision.
• Zyprexa (olanzapine): This antipsychotic medication is prescribed for both schizophrenia and bipolar I disorder maintenance. Though widely used, it comes with potential side effects that require careful monitoring by your doctor. 

Online Lamictal Prescription Through Talkspace 

Talkspace can help you get prescriptions for bipolar medications like Lamictal online. The convenience of the online platform makes getting medication an efficient, affordable, and secure process. Talkspace connects you with licensed mental health professionals to help you find the right treatment plan to reduce or resolve symptoms of bipolar disorder

Talkspace providers can offer therapy for bipolar disorder, prescribe medications, and provide ongoing medication management to ensure you’re getting optimal results and living your best life. 

Learn how to get Lamictal prescribed by an online psychiatrist today.